STOmics is a pioneer in advancing spatially-resolved transcriptomic analysis through its proprietary SpaTial Enhanced REsolution Omics-Sequencing (Stereo-seq) technology. Built on DNA Nanoball (DNB) technology, Stereo-seq offers researchers a novel tool to explore spatial biology with unprecedented field-of-view and resolution. Stereo-seq is performed in square-centimeter units, with the standard 1x1 cm RNA capture unit employing the STOmics-GeneExpression-S1 Chip. STOmics-GeneExpression-S1 combines centimeter-field-of-view in situ capture of whole transcriptome information with nanoscale resolution, powering the unrivaled quality of Stereo-seq. STOmics-GeneExpression-S1 enables researchers to perform spatial transcriptomic analysis at the tissue, cellular, subcellular, and molecular levels within one tissue sample. STOmics-GeneExpression-S1 Chips are patterned grids of probes containing spatial coordinates. Upon interaction with a tissue section, cDNA is synthesized in situ from mRNA captured by the chip probes. Sequencing the cDNA with their spatial coordinates allows in silico reconstitution of the spatial transcriptomic profile of the tissue section, allowing easy visualization and analysis.
"....Xun Xu, CEO of BGI Group, who directs BGI Research. He watches other company activities in this area and believes the BGI approach will have the highest resolution. The approach captures a few hundred data points per cell, says Xu." Nature Methods spotted great potential in BGI spatial omics innovation in a feature story in the January 2021 issue.
STOmics-GeneExpression-S1 Chips are patterned grids of probes containing spatial coordinates. Upon interaction with a tissue section, cDNA is synthesized in situ from mRNA captured by the chip probes. Sequencing the cDNA with their spatial coordinates allows in silico reconstitution of the spatial transcriptomic profile of the tissue section, allowing easy visualization and analysis.
STOmics-GeneExpression-S1 resolves the developmental structure-specific gene expression patterns in mouse embryos at centimeter-scale fields of view. A. Hematoxylin and eosin staining of an E16.5 embryo section. B. Unsupervised clustering analysis identifies different anatomical structures in the E16.5 embryo. C. Spatial expression heatmap of the indicated genes representing different developing structures in an E16.5 embryo section.
Dr. Ankur Sharma, Head of Onco-Fetal Ecosystem Laboratory at the Harry Perkins Institute of Medical Research, has partnered with BGI Australia to use Stereo-seq to reveal new ways of combating liver cancer.
The workshop features Dr. Quan Nguyen from the University of Queensland who talks about his frontier aging study; and Dr. Jennifer Currenti from Curtin University who talks about her team's carcinoma study.
The workshop features two guest speakers Dr. Dane Vassiliadis, Peter MacCallum Cancer Centre, and Dr. Ankur Sharma, Harry Perkins Institute sharing their exciting research using STOmics.
Watch the interview with Dr. Chris Chen, Co-founder of BGI STOmics, and find out the story behind BGI's latest spatial omics innovation.